Daily News

Role of “bad cholesterol” in triggering early-onset Alzheimer’s

Alzheimer’s is a progressive disease which affects memory as well as other relevant memory functions. While most people suffer from Alzheimer’s in their late years, rare conditions suffer from early-onset Alzheimer’s which occurs before the age of 65. The reasons responsible for early-onset Alzheimer’s are not yet fully comprehended by the scientists, yet they have significant doubts on the role of “ bad cholesterol” in it. The only determining factor is genetic, namely the expression of a variant of the gene APOE, called APOE E4, which also has an association with higher levels of circulating low-density lipoprotein (LDL) cholesterol. Earlier researches have shown that LDL cholesterol has adverse effects on health as its rise in level could lead to accumulation in arteries thus obstructing blood flow, which in turn leads to cardiovascular issues, hence known as bad cholesterol. A new study has revealed the connection of high (LDL) cholesterol with early-onset Alzheimer’s. Lead author Dr. Thomas Wingo says that their next agenda is to establish whether there is a causal link between cholesterol levels in the blood and Alzheimer's disease risk and that the current analysis has been vague about this. “ One interpretation of our current data is that LDL cholesterol does play a causal role. If that is the case, we might need to revise targets for LDC cholesterol to help reduce Alzheimer's risk," says Dr. Thomas Wingo.

Are energy drinks a threat to heart?

Energy drinks are said to improve concentration and ae famous for providing mental and physical stimulation. They are gaining fame amongst teenagers and young adults and has bagged the place of second most popular dietary supplement of choice. Its ingredients include caffeine, guarana, taurine, ginseng, and B vitamins which contribute to instant mood boosting effects in consumers and comes in various flavours and tastes. A study was conducted to analyse effect of energy drinks on health. In human body, time taken by heart chambers to contract and relax is called “QTc interval” of which, 450 milliseconds (ms) in men and 460 ms in women is considered the maximum for a healthy heart rhythm. After the study, researchers found a considerable change in the participants QTc interval. In volunteers who consumed the energy drinks, upto 4hrs of QTc interval length has been observed, which can lead to serious cardiac health issues. “We found an association between consuming energy drinks and changes in QT intervals and blood pressure that cannot be attributed to caffeine. We urgently need to investigate the particular ingredient or combination of ingredients in different types of energy drinks that might explain the findings seen in our clinical trial.", says Prof. Sachin A. Shah.