“Medical reversal” refers to when a newer and methodologically superior clinical trial produces results that contradict existing clinical practice and the older trials on which it is based. Through medical reversal, we come to know of existing practices which are ineffective or causes harm than good to patients. In a recent study, results show the existence of about 400 medical reversal cases. Studies were performed on 3,000 randomized controlled trials published in three prestigious medical journals over the last 15 years and 396 medical reversals were found. Once an ineffective practice is established, it may be difficult to convince practitioners to abandon its use. By aiming to test novel treatments rigorously before they become widespread, we can reduce the number of reversals in practice and prevent unnecessary harm to patients.", says Dr. Vinay Prasad, hematologist-oncologist and associate professor at the OHSU Knight Cancer Institute. From these examinations, the relevance of testing established practices as well as new practices are evident. The researchers believe that these finding promote medical professionals to test and make reconfirmations on their practices before adopting any method.