A protein has been discovered by scientists in the fat cells of mice, which when targeted has the capability to reverse or prevent Type 2 diabetes. Type 2 diabetes is the most common form of diabetes and 1 in 10 people suffers from it. When we eat more calories than our body needs, a type of fat called white adipose tissue (WAT) expands to store the excess energy as fat. However, if we take on more energy than we need for more extended periods, this system cannot cope, eventually leading to insulin resistance. Researchers used mice that lacked the gene that codes for CD248 in their WAT (although other cell types were still producing CD248). In these experiments, the researchers found that the mice were protected from developing insulin resistance and T2D. The mice did not develop diabetes, even when they were fed a high-fat diet and became obese. A most interesting finding was that the insulin sensitivity of mice that already have diabetes can be improved by reducing CD248 levels in the fat cells, even while they remain obese." Says Co-senior author Dr. Edward Conway. However, scientists say that the journey from research in cells and mice to treating human patients is a long, expensive, and often unsuccessful one.